Ancient Sanskrit texts including the Mahabharata, the Ramayana, and the Puranas explain the nagas as a robust, splendid and happy semi-divine species that may suppose their Actual physical sort both as human (normally by using a halo of cobra hoods at the rear of their head), being a partly human serpent, or in general serpent. Their area is inside the enchanted underworld, the underground realm stuffed with gems, gold together with other earthly treasures referred to as Naga-loka or Patala-loka. They're also usually related to bodies of waters — such as rivers, lakes, seas, and wells — and they are guardians of treasure.[10] Their electrical power and venom make them likely hazardous to individuals. Nonetheless, in Hindu mythology, they frequently take the role of benevolent protagonists; during the Samudra Manthana, Vasuki, a nagaraja who abides on Shiva's neck, turned the churning rope for churning of the Ocean of Milk.

The loss of activity is not as a consequence of a diminished ability to bind divalent cations For the reason that metal information with the purified mutants was identical to the wild style enzyme. The catalytic Attributes of such mutants are absolutely in line with the proposed role of this residue while in the chemical mechanism as the main typical foundation for activation with the hydrolytic h2o molecule and the next protonation of your leaving team amine.

there are tyrosine (Y223) and lysine (K139) residues that could also be contributing into the conversation Along with the phosphate moiety of your substrate. Deprotonation of either of such residues at superior pH could result in a drop in the value of k

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-acetyl-d-glucosamine-six-phosphate as illustrated in Plan 1. The deacetylation of the compound provides a source of carbon and nitrogen by planning this substrate for entry in to the glycolytic pathway. This response is usually a vital step from the catabolism of N

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